Topology optimization is typically used to determine the optimal distribution of a specified amount of material in a given package space. The technology has evolved from component design to full body structural design with multiple loading conditions. In this paper linear static load cases that are restrained with Single Point Constraint (SPC) boundary conditions are combined with unrestrained linear static equivalent collision load cases using inertial relief static solutions. Along with presenting the optimization results for a large Finite Element Model (FEM) this paper investigates the critical use of concentrated masses for topology optimization using inertial relief static solutions. The results provide a conceptual design that emphasizes the most efficient load paths. When taken into account during further design refinements the topology results will help determine the most lightweight and stiff Body-in-White (BIW) design for the applied loading conditions.