This paper describes GSAM (GENESIS Structural Optimization for ANSYS Mechanical) which is a computer application that integrates the GENESIS® structural optimization software with ANSYS® analysis software. One capability of GSAM is to allow its users to optimize structures in which their nonlinear responses are calculated by ANSYS®. GSAM utilizes GENESIS’s six types of optimizations which are : sizing, shape, topology, topometry, topography, and freeform. GSAM can utilize the Equivalent Static Load method. A key advantage of this method is that it only requires a small number of analysis calls. This advantage enables its users to optimize very large scale nonlinear problems in a reasonable amount of time. Three problems will be presented here to demonstrate this tool. The first example will highlight the ability of performing topology optimization with nonlinear transient analysis .The second example will show topology optimization for reducing plastic residual deformation. The third and last examples will demonstrate the optimization of a structure with nonlinear material using topography optimization.